AirHint found the following cheapest one-way flights from Rome (CIA) to Prague (PRG) in May 2026 (see full year).

One-Way flights

01 May	Ryanair	direct
28 May	Ryanair	direct
08 May	Ryanair	direct
07 May	Ryanair	direct
06 May	Ryanair	direct
23 May	Ryanair	direct
15 May	Ryanair	direct
16 May	Ryanair	direct
31 May	Ryanair	direct
29 May	Ryanair	direct

Also check the deals for return flights from Rome to Prague in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Rome to Prague in May from $64

One-Way flights