Cheapest one-way flights from Charlotte to Madrid in September from $269

Best time to book flights for Charlotte (CLT) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Charlotte (CLT) to Madrid (MAD) in September 2025 (see full year).

One-Way flights

14 Sep Spirit Airlines
18 Sep Spirit Airlines
05 Sep Spirit Airlines
06 Sep Spirit Airlines
18 Sep British Airways direct
14 Sep American Airlines direct
05 Sep American Airlines direct
06 Sep American Airlines direct

Also check the deals for return flights from Charlotte to Madrid in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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