Cheapest one-way flights from Des Moines to Rome in October from $193

AirHint found the following cheapest one-way flights from Des Moines (DSM) to Rome (FCO) in October 2025 (see full year).

One-Way flights

27 Oct Allegiant Air
15 Oct Allegiant Air
12 Oct Delta

Also check the deals for return flights from Des Moines to Rome in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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