Cheapest one-way flights from Des Moines to Guatemala City in October from $373

AirHint found the following cheapest one-way flights from Des Moines (DSM) to Guatemala City (GUA) in October 2025 (see full year).

One-Way flights

13 Oct Delta

Also check the deals for return flights from Des Moines to Guatemala City in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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