AirHint found the following cheapest one-way flights from Rome (FCO) to Palermo (PMO) in December 2025 (see full year).

One-Way flights

30 Dec	Ryanair	direct
29 Dec	Ryanair	direct
26 Dec	Ryanair	direct
28 Dec	Ryanair	direct
08 Dec	Ryanair	direct
02 Dec	Ryanair	direct
13 Dec	Ryanair	direct
09 Dec	ITA Airways	direct
27 Dec	Ryanair	direct
20 Dec	Ryanair	direct

Also check the deals for return flights from Rome to Palermo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Rome to Palermo in December from $40

One-Way flights