AirHint found the following cheapest one-way flights from Sao Paulo (GRU) to Santiago (SCL) in October 2025 (see full year).

One-Way flights

31 Oct	Sky Airline	direct
08 Oct	Sky Airline	direct
19 Oct	Sky Airline	direct
15 Oct	Sky Airline	direct
24 Oct	Sky Airline	direct
10 Oct	Sky Airline	direct
25 Oct	Sky Airline	direct
26 Oct	Sky Airline	direct
16 Oct	Sky Airline	direct
02 Oct	Sky Airline	direct

Also check the deals for return flights from Sao Paulo to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Sao Paulo to Santiago in October from $70

One-Way flights