AirHint found the following cheapest one-way flights from Sao Paulo (GRU) to Santiago (SCL) in November 2025 (see full year).

One-Way flights

03 Nov	Sky Airline	direct
22 Nov	Sky Airline	direct
20 Nov	Sky Airline	direct
26 Nov	Sky Airline	direct
06 Nov	Sky Airline	direct
04 Nov	Sky Airline	direct
13 Nov	Sky Airline	direct
24 Nov	Sky Airline	direct
25 Nov	Sky Airline	direct
05 Nov	LATAM Airlines Group

Also check the deals for return flights from Sao Paulo to Santiago in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Sao Paulo to Santiago in November from $72

One-Way flights