Cheapest one-way flights from Guatemala City to Santa Cruz in May from $260

Best time to book flights for Guatemala City (GUA) to Santa Cruz (VVI) flights at AirHint

AirHint found the following cheapest one-way flights from Guatemala City (GUA) to Santa Cruz (VVI) in May 2025 (see full year).

One-Way flights

28 May Avianca
01 May Avianca
08 May Copa

Also check the deals for return flights from Guatemala City to Santa Cruz in May.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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