AirHint found the following cheapest one-way flights from Guayaquil (GYE) to Panama City (PTY) in December 2025 (see full year).
One-Way flights
| 06 Dec | Avianca | ||
| 28 Dec | Avianca | ||
| 22 Dec | Copa | direct | |
| 28 Dec | Copa | direct | |
| 06 Dec | Copa | direct | |
| 29 Dec | Copa | direct |
Also check the deals for return flights from Guayaquil to Panama City in December.
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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
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