Cheapest one-way flights from Guayaquil to Santiago in December from $207

AirHint found the following cheapest one-way flights from Guayaquil (GYE) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

03 Dec Avianca
26 Dec Avianca
06 Dec Avianca
29 Dec Avianca
15 Dec Avianca
31 Dec Avianca
22 Dec LATAM Airlines Group
04 Dec LATAM Airlines Group direct
28 Dec LATAM Airlines Group direct
28 Dec Avianca

Also check the deals for return flights from Guayaquil to Santiago in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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