Cheapest one-way flights from Guayaquil to Santiago in December from $238

AirHint found the following cheapest one-way flights from Guayaquil (GYE) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

16 Dec Copa
11 Dec Copa
30 Dec Copa
30 Dec LATAM Airlines Group direct
16 Dec LATAM Airlines Group direct
11 Dec LATAM Airlines Group direct

Also check the deals for return flights from Guayaquil to Santiago in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Feel free to contact us with any feedback or request another flight research.