Cheapest one-way flights from Guayaquil to Santiago in April from $165

AirHint found the following cheapest one-way flights from Guayaquil (GYE) to Santiago (SCL) in April 2026 (see full year).

One-Way flights

10 Apr LATAM Airlines Group
09 Apr LATAM Airlines Group
13 Apr Avianca
02 Apr Avianca
03 Apr Avianca
08 Apr Avianca
04 Apr Avianca
07 Apr LATAM Airlines Group
07 Apr LATAM Airlines Group direct
05 Apr LATAM Airlines Group

Also check the deals for return flights from Guayaquil to Santiago in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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