Cheapest one-way flights from Guayaquil to Santiago in April from $249

AirHint found the following cheapest one-way flights from Guayaquil (GYE) to Santiago (SCL) in April 2026 (see full year).

One-Way flights

09 Apr LATAM Airlines Group direct
07 Apr LATAM Airlines Group direct
08 Apr LATAM Airlines Group direct
21 Apr Avianca
25 Apr LATAM Airlines Group
21 Apr LATAM Airlines Group direct
25 Apr LATAM Airlines Group direct

Also check the deals for return flights from Guayaquil to Santiago in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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