Cheapest one-way flights from Guayaquil to Santiago in September from $189

AirHint found the following cheapest one-way flights from Guayaquil (GYE) to Santiago (SCL) in September 2025 (see full year).

One-Way flights

30 Sep LATAM Airlines Group
11 Sep Copa
10 Sep Copa
15 Sep LATAM Airlines Group
25 Sep LATAM Airlines Group
12 Sep Copa
09 Sep LATAM Airlines Group
25 Sep LATAM Airlines Group direct
05 Sep Avianca
07 Sep Avianca

Also check the deals for return flights from Guayaquil to Santiago in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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