AirHint found the following cheapest one-way flights from Houston (HOU) to Santiago (SCL) in October 2025 (see full year).
One-Way flights
| 25 Oct | Spirit Airlines | ||
| 25 Oct | United | direct | |
| 22 Oct | Delta | ||
| 16 Oct | Delta |
Also check the deals for return flights from Houston to Santiago in October.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
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