Cheapest one-way flights from Houston to Santiago in December from $257

AirHint found the following cheapest one-way flights from Houston (IAH) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

10 Dec Spirit Airlines
11 Dec Spirit Airlines
16 Dec Spirit Airlines
23 Dec Frontier Airlines
30 Dec United direct
23 Dec United direct
11 Dec United direct
10 Dec United direct
16 Dec United direct
22 Dec United direct

Also check the deals for return flights from Houston to Santiago in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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