Cheapest one-way flights from Los Angeles to Santiago in April from $291

AirHint found the following cheapest one-way flights from Los Angeles (LAX) to Santiago (SCL) in April 2026 (see full year).

One-Way flights

22 Apr WestJet
07 Apr Spirit Airlines
06 Apr Frontier Airlines
30 Apr Avianca
30 Apr LATAM Airlines Group direct
03 Apr Frontier Airlines
22 Apr Delta direct
19 Apr LATAM Airlines Group direct
14 Apr LATAM Airlines Group
17 Apr LATAM Airlines Group

Also check the deals for return flights from Los Angeles to Santiago in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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