Cheapest one-way flights from Madrid to Brussels in December from $53

AirHint found the following cheapest one-way flights from Madrid (MAD) to Brussels (BRU) in December 2025 (see full year).

One-Way flights

17 Dec Ryanair direct
21 Dec Iberia
06 Dec Iberia
02 Dec Vueling Airlines direct
15 Dec Ryanair direct
16 Dec Ryanair direct
25 Dec Vueling Airlines direct
24 Dec Iberia direct
09 Dec Ryanair direct
06 Dec Ryanair direct

Also check the deals for return flights from Madrid to Brussels in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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