AirHint found the following cheapest one-way flights from Madrid (MAD) to Prague (PRG) in December 2025 (see full year).

One-Way flights

11 Dec	Wizz Air Malta
12 Dec	Wizz Air Malta
07 Dec	Ryanair	direct
15 Dec	Iberia
15 Dec	Ryanair	direct
06 Dec	Wizz Air Malta
28 Dec	Iberia	direct
24 Dec	Iberia	direct
08 Dec	Iberia	direct
12 Dec	Iberia	direct

Also check the deals for return flights from Madrid to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Prague

Cheap car rent in Prague

Cheapest one-way flights from Madrid to Prague in December from $67

One-Way flights