AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in January 2026 (see full year).

One-Way flights

04 Jan	Boliviana de Aviacion	direct
27 Jan	Avianca
20 Jan	Avianca
21 Jan	Avianca
28 Jan	Avianca
28 Jan	Air Europa	direct
01 Jan	LATAM Airlines Group
21 Jan	Air Europa	direct
14 Jan	Iberia	direct
13 Jan	LATAM Airlines Group

Also check the deals for return flights from Madrid to Santa Cruz in January.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Madrid to Santa Cruz in January from $429

One-Way flights