Cheapest one-way flights from Madrid to Santa Cruz in April from $482

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in April 2026 (see full year).

One-Way flights

20 Apr Air Europa direct
03 Apr Boliviana de Aviacion direct
17 Apr Iberia direct
01 Apr Iberia direct
10 Apr Iberia direct
30 Apr LATAM Airlines Group
09 Apr LATAM Airlines Group
04 Apr LATAM Airlines Group
04 Apr Air Europa direct

Also check the deals for return flights from Madrid to Santa Cruz in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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