AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in June 2025 (see full year).

One-Way flights

17 Jun	Boliviana de Aviacion
15 Jun	Boliviana de Aviacion	direct
18 Jun	Avianca
19 Jun	Avianca
16 Jun	Avianca
18 Jun	Iberia	direct
30 Jun	LATAM Airlines Group
24 Jun	Boliviana de Aviacion
22 Jun	Boliviana de Aviacion	direct
25 Jun	Avianca

Also check the deals for return flights from Madrid to Santa Cruz in June.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Madrid to Santa Cruz in June from $413

One-Way flights