Cheapest one-way flights from Orlando to Panama City in October from $165

AirHint found the following cheapest one-way flights from Orlando (MCO) to Panama City (PTY) in October 2025 (see full year).

One-Way flights

23 Oct Spirit Airlines
19 Oct Volaris Costa Rica
07 Oct Spirit Airlines
26 Oct Avianca
15 Oct Spirit Airlines
15 Oct Copa direct
26 Oct Copa direct
01 Oct Copa direct
07 Oct Copa direct
23 Oct Copa direct

Also check the deals for return flights from Orlando to Panama City in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Feel free to contact us with any feedback or request another flight research.