Cheapest one-way flights from Rio Negro to Sao Paulo in December from $257

AirHint found the following cheapest one-way flights from Rio Negro (MDE) to Sao Paulo (GRU) in December 2025 (see full year).

One-Way flights

06 Dec LATAM Airlines Group
08 Dec LATAM Airlines Group
07 Dec LATAM Airlines Group
04 Dec Copa
23 Dec Copa
29 Dec Copa
22 Dec LATAM Airlines Group
20 Dec LATAM Airlines Group
21 Dec LATAM Airlines Group
10 Dec GOL Linhas Aéreas

Also check the deals for return flights from Rio Negro to Sao Paulo in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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