Cheapest one-way flights from Rio Negro to Guayaquil in December from $175

AirHint found the following cheapest one-way flights from Rio Negro (MDE) to Guayaquil (GYE) in December 2025 (see full year).

One-Way flights

26 Dec Copa
16 Dec Copa
19 Dec Copa
31 Dec Copa
15 Dec Copa
22 Dec Copa
19 Dec Avianca direct
15 Dec Avianca direct
26 Dec Avianca direct
29 Dec Avianca direct

Also check the deals for return flights from Rio Negro to Guayaquil in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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