Cheapest one-way flights from Rio Negro to Guayaquil in September from $197

AirHint found the following cheapest one-way flights from Rio Negro (MDE) to Guayaquil (GYE) in September 2025 (see full year).

One-Way flights

21 Sep Avianca
19 Sep Avianca direct
20 Sep Avianca
17 Sep Copa

Also check the deals for return flights from Rio Negro to Guayaquil in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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