AirHint found the following cheapest one-way flights from Rio Negro (MDE) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

15 Dec	JetSmart
14 Dec	JetSmart	direct
09 Dec	JetSmart
05 Dec	JetSmart
15 Dec	JetSmart	direct
07 Dec	JetSmart	direct
05 Dec	JetSmart	direct
17 Dec	JetSmart
11 Dec	JetSmart	direct
21 Dec	JetSmart	direct

Also check the deals for return flights from Rio Negro to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest one-way flights from Rio Negro to Santiago in December from $137

One-Way flights