Cheapest one-way flights from Chicago to Rome in December from $158

AirHint found the following cheapest one-way flights from Chicago (MDW) to Rome (FCO) in December 2025 (see full year).

One-Way flights

02 Dec Frontier Airlines
09 Dec Frontier Airlines
07 Dec Frontier Airlines
01 Dec Frontier Airlines
05 Dec Frontier Airlines
04 Dec Frontier Airlines
11 Dec Frontier Airlines
16 Dec Frontier Airlines
25 Dec Frontier Airlines
08 Dec Air France

Also check the deals for return flights from Chicago to Rome in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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