Cheapest one-way flights from Chicago to Panama City in December from $835

AirHint found the following cheapest one-way flights from Chicago (MDW) to Panama City (PTY) in December 2025 (see full year).

One-Way flights

10 Dec Delta

Also check the deals for return flights from Chicago to Panama City in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Feel free to contact us with any feedback or request another flight research.