Cheapest one-way flights from Chicago to Rome in April from $242

AirHint found the following cheapest one-way flights from Chicago (ORD) to Rome (FCO) in April 2026 (see full year).

One-Way flights

21 Apr Icelandair
16 Apr Icelandair
15 Apr Spirit Airlines
12 Apr Icelandair
26 Apr Air Canada
20 Apr Aer Lingus
19 Apr Icelandair
08 Apr Icelandair
29 Apr Spirit Airlines
17 Apr Icelandair

Also check the deals for return flights from Chicago to Rome in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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