Cheapest one-way flights from Chicago to Istanbul in September from $242

AirHint found the following cheapest one-way flights from Chicago (ORD) to Istanbul (IST) in September 2025 (see full year).

One-Way flights

23 Sep Spirit Airlines
27 Sep Spirit Airlines
06 Sep Spirit Airlines
25 Sep Spirit Airlines
20 Sep Frontier Airlines
13 Sep Spirit Airlines
05 Sep Frontier Airlines
19 Sep Frontier Airlines
17 Sep Frontier Airlines
08 Sep Frontier Airlines

Also check the deals for return flights from Chicago to Istanbul in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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