Cheapest one-way flights from Chicago to Prague in May from $380

Best time to book flights for Chicago (ORD) to Prague (PRG) flights at AirHint

AirHint found the following cheapest one-way flights from Chicago (ORD) to Prague (PRG) in May 2025 (see full year).

One-Way flights

28 May Spirit Airlines
24 May Hawaiian Airlines
26 May Spirit Airlines
29 May Spirit Airlines
18 May Frontier Airlines
17 May Spirit Airlines
21 May Air Canada
23 May Frontier Airlines
20 May Spirit Airlines
19 May Frontier Airlines

Also check the deals for return flights from Chicago to Prague in May.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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