AirHint found the following cheapest one-way flights from Chicago (ORD) to Santiago (SCL) in December 2025 (see full year).
One-Way flights
| 14 Dec | Spirit Airlines | ||
| 25 Dec | Frontier Airlines | ||
| 28 Dec | United | ||
| 22 Dec | Spirit Airlines | ||
| 18 Dec | Copa | ||
| 21 Dec | Frontier Airlines |
Also check the deals for return flights from Chicago to Santiago in December.
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