Cheapest one-way flights from Prestwick to Prague in December from $249

AirHint found the following cheapest one-way flights from Prestwick (PIK) to Prague (PRG) in December 2025 (see full year).

One-Way flights

30 Dec Ryanair
28 Dec Ryanair
29 Dec Ryanair

Also check the deals for return flights from Prestwick to Prague in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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