Cheapest one-way flights from Roanoke VA to Madrid in October from $438

AirHint found the following cheapest one-way flights from Roanoke VA (ROA) to Madrid (MAD) in October 2025 (see full year).

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.