AirHint found the following cheapest one-way flights from Rome (ROM) to Prague (PRG) in April 2026 (see full year).

One-Way flights

01 Apr	Wizz Air Malta	direct
12 Apr	Wizz Air Malta	direct
10 Apr	Wizz Air Malta	direct
04 Apr	Wizz Air Malta	direct
17 Apr	Wizz Air Malta	direct
18 Apr	Wizz Air Malta	direct
07 Apr	Wizz Air Malta	direct
16 Apr	Ryanair	direct

Also check the deals for return flights from Rome to Prague in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Rome to Prague in April from $46

One-Way flights