Cheapest one-way flights from Santiago to Guayaquil in October from $201

AirHint found the following cheapest one-way flights from Santiago (SCL) to Guayaquil (GYE) in October 2025 (see full year).

One-Way flights

15 Oct Avianca
16 Oct LATAM Airlines Group direct
16 Oct Avianca
22 Oct LATAM Airlines Group direct
22 Oct Avianca
14 Oct Avianca
07 Oct Avianca
06 Oct LATAM Airlines Group direct
05 Oct LATAM Airlines Group direct
05 Oct Avianca

Also check the deals for return flights from Santiago to Guayaquil in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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