Cheapest one-way flights from Santiago to Guayaquil in October from $149

AirHint found the following cheapest one-way flights from Santiago (SCL) to Guayaquil (GYE) in October 2025 (see full year).

One-Way flights

01 Oct LATAM Airlines Group direct
15 Oct LATAM Airlines Group
06 Oct Avianca
15 Oct LATAM Airlines Group direct
05 Oct LATAM Airlines Group
14 Oct LATAM Airlines Group
28 Oct Copa
06 Oct LATAM Airlines Group direct
05 Oct LATAM Airlines Group direct
14 Oct LATAM Airlines Group direct

Also check the deals for return flights from Santiago to Guayaquil in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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