Cheapest one-way flights from Santiago to Guayaquil in April from $162

AirHint found the following cheapest one-way flights from Santiago (SCL) to Guayaquil (GYE) in April 2026 (see full year).

One-Way flights

16 Apr LATAM Airlines Group
13 Apr LATAM Airlines Group
06 Apr LATAM Airlines Group
22 Apr LATAM Airlines Group
21 Apr LATAM Airlines Group
15 Apr LATAM Airlines Group
11 Apr LATAM Airlines Group
09 Apr LATAM Airlines Group
08 Apr LATAM Airlines Group
14 Apr LATAM Airlines Group

Also check the deals for return flights from Santiago to Guayaquil in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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