Cheapest one-way flights from Santiago to Guayaquil in May from $174

Best time to book flights for Santiago (SCL) to Guayaquil (GYE) flights at AirHint

AirHint found the following cheapest one-way flights from Santiago (SCL) to Guayaquil (GYE) in May 2025 (see full year).

One-Way flights

25 May Copa
30 May Copa
31 May Avianca
13 May Copa
30 May LATAM Airlines Group direct
21 May Sky Airline
25 May LATAM Airlines Group direct
20 May LATAM Airlines Group
15 May LATAM Airlines Group
17 May LATAM Airlines Group

Also check the deals for return flights from Santiago to Guayaquil in May.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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