Cheapest one-way flights from Santiago to Madrid in December from $391

AirHint found the following cheapest one-way flights from Santiago (SCL) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

06 Dec LATAM Airlines Group
08 Dec Sky Airline
09 Dec LATAM Airlines Group
05 Dec LATAM Airlines Group
04 Dec LATAM Airlines Group
02 Dec Aerolineas Argentinas
01 Dec LATAM Airlines Group
03 Dec LATAM Airlines Group
10 Dec LATAM Airlines Group
02 Dec Iberia direct

Also check the deals for return flights from Santiago to Madrid in December.

Powered by

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid

Feel free to contact us with any feedback or request another flight research.