AirHint found the following cheapest one-way flights from Santiago (SCQ) to Rome (FCO) in September 2025 (see full year).

One-Way flights

23 Sep	Vueling Airlines
24 Sep	Vueling Airlines
29 Sep	Vueling Airlines
16 Sep	Vueling Airlines
22 Sep	Vueling Airlines
26 Sep	Ryanair
25 Sep	Vueling Airlines
27 Sep	Vueling Airlines
17 Sep	Vueling Airlines
20 Sep	Ryanair

Also check the deals for return flights from Santiago to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Santiago to Rome in September from $66

One-Way flights