Cheapest one-way flights from San Francisco to Sao Paulo in April from $280

AirHint found the following cheapest one-way flights from San Francisco (SFO) to Sao Paulo (GRU) in April 2026 (see full year).

One-Way flights

06 Apr LATAM Airlines Group
07 Apr LATAM Airlines Group
14 Apr LATAM Airlines Group
15 Apr LATAM Airlines Group
16 Apr LATAM Airlines Group
13 Apr LATAM Airlines Group
12 Apr LATAM Airlines Group
08 Apr LATAM Airlines Group
27 Apr LATAM Airlines Group
01 Apr LATAM Airlines Group

Also check the deals for return flights from San Francisco to Sao Paulo in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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