Cheapest one-way flights from San Francisco to Santiago in November from $278

AirHint found the following cheapest one-way flights from San Francisco (SFO) to Santiago (SCL) in November 2025 (see full year).

One-Way flights

15 Nov Frontier Airlines
16 Nov Copa
14 Nov American Airlines
23 Nov American Airlines
29 Nov American Airlines
09 Nov American Airlines
03 Nov American Airlines
30 Nov American Airlines
19 Nov Frontier Airlines
08 Nov LATAM Airlines Group

Also check the deals for return flights from San Francisco to Santiago in November.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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