Cheapest one-way flights from San Francisco to Santiago in April from $265

AirHint found the following cheapest one-way flights from San Francisco (SFO) to Santiago (SCL) in April 2026 (see full year).

One-Way flights

01 Apr LATAM Airlines Group
02 Apr LATAM Airlines Group
08 Apr LATAM Airlines Group
10 Apr LATAM Airlines Group
11 Apr LATAM Airlines Group
12 Apr LATAM Airlines Group
18 Apr LATAM Airlines Group
19 Apr LATAM Airlines Group
22 Apr LATAM Airlines Group
28 Apr LATAM Airlines Group

Also check the deals for return flights from San Francisco to Santiago in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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