AirHint found the following cheapest one-way flights from Split (SPU) to Istanbul (IST) in September 2025 (see full year).

One-Way flights

16 Sep	Vueling Airlines
25 Sep	Ryanair
08 Sep	Wizz Air UK
10 Sep	Wizz Air UK
09 Sep	Vueling Airlines
11 Sep	Wizz Air UK
18 Sep	Air Serbia
06 Sep	Croatia Airlines
28 Sep	Volotea
09 Sep	Croatia Airlines	direct

Also check the deals for return flights from Split to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Split to Istanbul in September from $80

One-Way flights