AirHint found the following cheapest return flights from Amsterdam (AMS) to Madrid (MAD) in September 2025 (see full year).

Return flights

23 Sep - 30 Sep	Ryanair
23 Sep - 27 Sep	Ryanair
25 Sep - 30 Sep	Ryanair
08 Sep - 30 Sep	Ryanair
08 Sep - 13 Sep	Ryanair
14 Sep - 17 Sep	Ryanair
23 Sep - 28 Sep	Ryanair
08 Sep - 10 Sep	Ryanair
23 Sep - 25 Sep	Ryanair
13 Sep - 16 Sep	Ryanair
25 Sep - 08 Oct	Ryanair
23 Sep - 04 Oct	Iberia	direct
24 Sep - 07 Oct	Ryanair
30 Sep - 07 Oct	Ryanair
25 Sep - 02 Oct	Ryanair
24 Sep - 08 Oct	Ryanair
24 Sep - 06 Oct	Iberia	direct
25 Sep - 01 Oct	Ryanair
25 Sep - 09 Oct	Ryanair
20 Sep - 04 Oct	Ryanair

Also check the deals for one-way flights from Amsterdam to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Amsterdam to Madrid in September from $141

Return flights