AirHint found the following cheapest return flights from Amsterdam (AMS) to Panama City (PTY) in October 2025 (see full year).

Return flights

28 Oct - 19 Nov	Air France
02 Oct - 06 Oct	Air France
28 Oct - 21 Nov	Air France
18 Oct - 25 Oct	United
30 Oct - 10 Nov	Lufthansa
24 Oct - 04 Nov	United
01 Oct - 14 Nov	United
08 Oct - 29 Oct	United
01 Oct - 31 Oct	United
10 Oct - 17 Oct	United
03 Oct - 10 Oct	United
07 Oct - 10 Oct	Delta
25 Oct - 01 Nov	Delta
06 Oct - 10 Oct	Delta
15 Oct - 30 Oct	Delta
28 Oct - 19 Nov	KLM	direct
01 Oct - 14 Nov	KLM	direct
24 Oct - 04 Nov	KLM	direct
08 Oct - 29 Oct	KLM	direct
30 Oct - 10 Nov	KLM	direct

Also check the deals for one-way flights from Amsterdam to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Amsterdam to Panama City in October from $718

Return flights