AirHint found the following cheapest return flights from Amsterdam (AMS) to Panama City (PTY) in October 2025 (see full year).

Return flights

31 Oct - 09 Nov	Air Europa
31 Oct - 21 Nov	Air Europa
24 Oct - 17 Nov	Air Europa
04 Oct - 11 Oct	Delta
08 Oct - 15 Oct	Delta
20 Oct - 27 Oct	Delta
16 Oct - 30 Oct	Delta
22 Oct - 04 Nov	KLM
27 Oct - 11 Nov	KLM
27 Oct - 02 Nov	Ryanair
23 Oct - 17 Nov	Air Europa
22 Oct - 04 Nov	KLM	direct
14 Oct - 30 Oct	Delta
14 Oct - 11 Nov	Delta
06 Oct - 25 Oct	Ryanair
08 Oct - 10 Oct	Ryanair
11 Oct - 14 Oct	Air Europa
11 Oct - 15 Oct	Ryanair
07 Oct - 16 Oct	KLM	direct

Also check the deals for one-way flights from Amsterdam to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Amsterdam to Panama City in October from $689

Return flights