AirHint found the following cheapest return flights from Amsterdam (AMS) to Panama City (PTY) in December 2025 (see full year).

Return flights

06 Dec - 28 Dec	United
25 Dec - 24 Jan	United
06 Dec - 29 Dec	United
12 Dec - 12 Jan	United
28 Dec - 21 Jan	United
29 Dec - 20 Jan	United
25 Dec - 08 Jan	United
29 Dec - 19 Jan	United
28 Dec - 20 Jan	United
28 Dec - 11 Jan	United
28 Dec - 19 Jan	United
02 Dec - 11 Dec	KLM
24 Dec - 30 Jan	United
02 Dec - 11 Dec	KLM	direct
01 Dec - 11 Dec	Turkish Airlines
19 Dec - 31 Dec	United
01 Dec - 11 Dec	KLM	direct
20 Dec - 31 Dec	Air Europa

Also check the deals for one-way flights from Amsterdam to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Amsterdam to Panama City in December from $653

Return flights