AirHint found the following cheapest return flights from Antofagasta (ANF) to Santiago (SCL) in April 2026 (see full year).

Return flights

10 Apr - 12 Apr	Sky Airline
10 Apr - 13 Apr	Sky Airline
10 Apr - 14 Apr	Sky Airline
10 Apr - 14 Apr	Sky Airline	direct
10 Apr - 12 Apr	JetSmart	direct
16 Apr - 29 Apr	Sky Airline
22 Apr - 24 May	Sky Airline
12 Apr - 14 Apr	JetSmart	direct
12 Apr - 16 Apr	JetSmart	direct
10 Apr - 16 Apr	JetSmart	direct
13 Apr - 14 Apr	JetSmart	direct
29 Apr - 19 May	JetSmart	direct
22 Apr - 24 May	Sky Airline	direct

Also check the deals for one-way flights from Antofagasta to Santiago in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Antofagasta to Santiago in April from $81

Return flights