AirHint found the following cheapest return flights from Arequipa (AQP) to Santiago (SCL) in December 2025 (see full year).

Return flights

30 Dec - 16 Jan	JetSmart
29 Dec - 16 Jan	JetSmart
22 Dec - 11 Jan	JetSmart
30 Dec - 13 Jan	JetSmart
30 Dec - 11 Jan	JetSmart
29 Dec - 11 Jan	JetSmart
30 Dec - 06 Jan	Sky Airline
29 Dec - 06 Jan	Sky Airline
29 Dec - 08 Jan	LATAM Airlines Group
28 Dec - 16 Jan	JetSmart
18 Dec - 30 Dec	JetSmart
22 Dec - 30 Dec	JetSmart
18 Dec - 22 Dec	Sky Airline
29 Dec - 30 Dec	JetSmart
28 Dec - 30 Dec	JetSmart
23 Dec - 30 Dec	JetSmart
18 Dec - 25 Dec	JetSmart
22 Dec - 25 Dec	JetSmart
23 Dec - 25 Dec	JetSmart

Also check the deals for one-way flights from Arequipa to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Arequipa to Santiago in December from $434

Return flights