AirHint found the following cheapest return flights from Asuncion (ASU) to Santiago (SCL) in September 2025 (see full year).

Return flights

30 Sep - 15 Oct	JetSmart
30 Sep - 07 Oct	JetSmart
30 Sep - 08 Oct	JetSmart
30 Sep - 21 Oct	JetSmart
30 Sep - 04 Oct	JetSmart
30 Sep - 16 Oct	JetSmart
30 Sep - 20 Oct	JetSmart
30 Sep - 01 Oct	JetSmart
30 Sep - 10 Oct	JetSmart
30 Sep - 09 Oct	JetSmart
19 Sep - 23 Sep	JetSmart
19 Sep - 30 Sep	JetSmart
23 Sep - 30 Sep	JetSmart
23 Sep - 26 Sep	JetSmart
25 Sep - 30 Sep	JetSmart
25 Sep - 28 Sep	Aerolineas Argentinas
24 Sep - 27 Sep	Aerolineas Argentinas
25 Sep - 26 Sep	JetSmart
29 Sep - 30 Sep	JetSmart
28 Sep - 30 Sep	JetSmart

Also check the deals for one-way flights from Asuncion to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Asuncion to Santiago in September from $335

Return flights