AirHint found the following cheapest return flights from Boston (BOS) to Santiago (SCL) in December 2025 (see full year).

Return flights

03 Dec - 10 Dec	LATAM Airlines Group
07 Dec - 14 Dec	LATAM Airlines Group
07 Dec - 18 Dec	United
10 Dec - 17 Dec	United
10 Dec - 18 Dec	United
09 Dec - 18 Dec	United
10 Dec - 19 Dec	United
11 Dec - 17 Dec	Delta
11 Dec - 14 Dec	Delta
04 Dec - 18 Dec	Copa
11 Dec - 13 Jan	Spirit Airlines
31 Dec - 17 Jan	LATAM Airlines Group
29 Dec - 11 Jan	LATAM Airlines Group
13 Dec - 16 Jan	Spirit Airlines
15 Dec - 05 Jan	Spirit Airlines
24 Dec - 02 Jan	Frontier Airlines
13 Dec - 05 Jan	Spirit Airlines
20 Dec - 09 Jan	Spirit Airlines
25 Dec - 01 Jan	LATAM Airlines Group
23 Dec - 04 Jan	Spirit Airlines

Also check the deals for one-way flights from Boston to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Boston to Santiago in December from $523

Return flights